Tranexamic acid (TA) was determined spectrophotometrically after derivatizing with salicylaldehyde (SA) or 5, 5’-methylene-bis-salicylaldehyde (BSA) at neutral pH in aqueous-methanolic solution. The reaction conditions were optimized and the derivatives absorbed maximally at 410nm and 412nm for SA and BSA respectively. The Beer’s law was obeyed in the range 7.8-18.6 mg/ml tranexamic acid, with coefficient of determination of 0.9995 and 0.9998. The methods were applied for the determination of tranexamic acid in pharmaceutical preparations with coefficient of variation 0.76-0.97%.
F M A RIND ,K F ALMANI ,M Y KHUHAWAR ,A D RAJPAR ,
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