A new differential potentiometric technique bas~d on a simple, inexpensive RC filter circuit, capable of producing primary derivative signals, is presented for quantitative differential poten­tiometric work. The relevant experimental set-up to carry out automa­tic potentiometric titrations is designed and its performance is demonstrated for various weak/strong acid-base combinations. The technique has the potential of application to other areas of poten­tiometric estimation such as compleximetry and redox titrimetry. The overa 11 average accuracy of the method when app 1 i ed to a set of 16 acid-base combinations turns out to be about 1.5% with a precision of ± 1% in duplicate runs.