Antibacterial Co(II) Complexes of Benzothiazole-Derived Compounds

Reaction of 2-acetamidobenzaldehyde with 2-amin0-4-methoxy-, 2-amino-4­chloro-, 2-amino-6-nitro- and 2-amino-6-methylsulfonyl benzothiazole afforded a series of congeners which have been further used for complexation reaction to obtain potential Co(II) compounds. The title compounds of the type [M(L)21x", where M=Co(II), L=L'-L4 of Fig.l, X=N03', 80/', C20/' or CH3C02' and n=1 or 2, have been characterized by physical, spectral, an.d analytical data. The compounds act tridentately and their metal (II) complexes are proposed to possess an ,octahedral geometry about the central metal atom. These compounds in comparison to their metal complexes have been screened for antibacterial properties against the pathogenic species Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

Z H CHOHAN ,H PERVEZ ,C T SUPURAN ,A SCOZZAFAVA ,