The peripherally tetra-substituted zinc (II) and cobalt (II) phthalocyanine complexes containing diethyl 3,4-dicyanophenylmalonate were synthesized and charaterized. These newly synthesized complexes have been described by utilizing FT-IR and UV/Vis procedures. Electronic absorption, fluorescence, melting denaturation, viscosity and electrophoresis procedures were applied to evaluate the interaction mechanism of tetra substituted 4 and 5 complexes with CT-DNA. Electronic spectra and emission experiments confirmed that 4 and 5 interact substantially by CT-DNA. The binding constant values for 4 and 5 were determined as 1.87 x106 M-1 and 1.64 x106 M-1, respectively. Kb data disclosed that the complexes attach to DNA through an intercalative binding mechanism. The results obtained from melting point technique also confirmed that the attachment of 4 and 5 complexes to DNA is an intercalative manner. In addition to above techniques, electrophoresis and viscosity technique were utilized to explain interaction features of 4 and 5 complexes with DNA. The findings obtained from viscosity and electrophoresis procedures demonstrated that the complexes interact with the DNA. All the data verified that 4 and 5 complexes may have a potential anticancer features
Ali Arslantaş and Mehmet S. Ağırtaş
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