Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 µM), 27 (IC50 = 234.83 ± 10.28 µM), 2 (IC50 = 240.99 ± 4.2 µM), and 14 (IC50 = 276.2 ± 2.3 µM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 µM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.
KHALID MOHAMMED KHAN, MUHAMMAD TAHA, FAZAL RAHIM, MUHAMMAD IMRAN FAKHRI, WAQAS JAMIL, MOMIN KHAN, SAIMA RASHEED, ANEELA KARIM, SHAHNAZ PERVEEN AND MOHAMMAD IQBAL CHOUDHARY
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